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Showing 1 to 12 of 357 entries
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Agomelatine protects heart and aorta against lipopolysaccharide-induced cardiovascular toxicity via inhibition of NF-kβ phosphorylation.

Drug and chemical toxicology

Asci H, Ozmen O, Erzurumlu Y, Sofu A, Icten P, Kaynak M.
PMID: 31514555
Drug Chem Toxicol. 2019 Sep 13;1-10. doi: 10.1080/01480545.2019.1663209. Epub 2019 Sep 13.

The aim of this study was to investigate the possible ameliorating effects of agomelatine (AGO) on lipopolysaccharide (LPS)-induced endothelial and cardiac damage. Twenty-four female Wistar Albino rats divided into 3 groups as follows: Control, LPS and LPS + AGO....

Oxidative damage to membrane lipids in the thyroid - no differences between sexes.

Drug and chemical toxicology

Stepniak J, Lewinski A, Karbownik-Lewinska M.
PMID: 31373249
Drug Chem Toxicol. 2021 Nov;44(6):655-660. doi: 10.1080/01480545.2019.1643878. Epub 2019 Aug 02.

It has long been observed that thyroid diseases are more prevalent in women than in men. However, there are limited experimental data demonstrating mechanisms by which sex differences in thyroid diseases may occur and exact molecular mechanisms involved are...

Do steviol glycosides affect the oxidative and genotoxicity parameters in BALB/c mice?.

Drug and chemical toxicology

Yılmaz ŞG, Uçar A, Yılmaz S.
PMID: 31959022
Drug Chem Toxicol. 2020 Jan 21;1-6. doi: 10.1080/01480545.2020.1716000. Epub 2020 Jan 21.

This study was performed with 40 (20 males, 20 females) BALB/c mice divided into 4 experimental groups and a control group, each consisting of 8 mice (4 males, 4 females). Experimental groups were administered 470, 620, 940, and 1880...

Different outcomes of methadone maintenance therapy in rehabilitated and relapsed drug addicts: significance of liver and renal biomarkers.

Drug and chemical toxicology

Suljević D, Šiljak A, Fočak M.
PMID: 32013636
Drug Chem Toxicol. 2020 Feb 03;1-6. doi: 10.1080/01480545.2020.1722157. Epub 2020 Feb 03.

Methadone eliminates heroin use, reduces death rates and criminality associated with heroin use, and improves patients' health and social productivity. This study included long-term addicts who completed a methadone therapy program as well as relapsed patients. Liver and renal...

25I-NBOMe, a phenethylamine derivative, induces adverse cardiovascular effects in rodents: possible involvement of p21 (CDC42/RAC)-activated kinase 1.

Drug and chemical toxicology

Yoon KS, Gu SM, Cha HJ, Kim YH, Yun J, Lee JM.
PMID: 32597268
Drug Chem Toxicol. 2020 Jun 29;1-9. doi: 10.1080/01480545.2020.1784924. Epub 2020 Jun 29.

Abuse of new psychoactive substances is an emerging social problem. Several phenethylamines are internationally controlled substances as they are likely to be abused and have adverse effects. Phenethylamine analog 2-(4-iodo-2,5-dimethoxyphenyl)-

Chemopreventive role of arabinogalactan against experimentally induced pulmonary carcinogenesis: a study in relation to its initiation phase.

Drug and chemical toxicology

Koul A, Garg S, Mohan V.
PMID: 31379226
Drug Chem Toxicol. 2021 Nov;44(6):642-654. doi: 10.1080/01480545.2019.1643877. Epub 2019 Aug 05.

The aim of the present study is to divulge the chemopreventive potential of arabinogalactan (AG) on benzo(a)pyrene [B(a)P] induced initiation of lung carcinogenesis. AG is one of the naturally occurring bioactive polysaccharides which is widely found in medicinal plants....

Ochratoxin a in breast milk in Morocco: the affecting dietary habits of the lactating mothers and the degree of exposure of newborns "CONTAMILK study".

Drug and chemical toxicology

Cherkani-Hassani A, Ghanname I, Zinedine A, Sefrioui H, Qmichou Z, Mouane N.
PMID: 32838562
Drug Chem Toxicol. 2020 Aug 24;1-7. doi: 10.1080/01480545.2020.1808669. Epub 2020 Aug 24.

The aim of the present study is to evaluate the level of contamination of breast milk (BM) by ochratoxin A, among Moroccan lactating mothers in the city of Rabat, and to identify the associated factors of exposure, also to...

Adverse effects of textile dyes on antioxidant enzymes and cholinesterase activities in .

Drug and chemical toxicology

Rahimi S, Singh MP, Gupta J.
PMID: 32838564
Drug Chem Toxicol. 2020 Aug 24;1-9. doi: 10.1080/01480545.2020.1809671. Epub 2020 Aug 24.

The effluents from textile dyeing industry are causing water pollution and may transform into more toxic and carcinogenic chemical species by environmental conditions. Therefore systemic toxicity of textile dyes is major health concern. Hence, this study sought to examine...

Drug and chemical toxicology

Ben Hsouna A, Dhibi S, Dhifi W, Ben Saad R, Brini F, Hfaidh N, Almeida JRGDS, Mnif W.
PMID: 32228118
Drug Chem Toxicol. 2020 Mar 31;1-14. doi: 10.1080/01480545.2020.1742730. Epub 2020 Mar 31.

No abstract available.

Escin attenuates oxidative damage, apoptosis and lipid peroxidation in a model of cyclophosphamide-induced liver damage.

Drug and chemical toxicology

Cengiz M, Kutlu HM, Peker Cengiz B, Ayhancı A.
PMID: 32838567
Drug Chem Toxicol. 2020 Aug 24;1-8. doi: 10.1080/01480545.2020.1810262. Epub 2020 Aug 24.

To investigate the effects of escin (ES) on acute damage induced by alkylating agent, experimental rats were injected with cyclophosphamide (CPM) to cause liver damage. The animals were divided into four groups: Control Group, CPM (200 mg/kg), ES (10...

Real-time monitoring of cellular oxidative stress during aerosol sampling: a proof of concept study.

Drug and chemical toxicology

Secondo LE, Avrutin V, Ozgur U, Topsakal E, Lewinski NA.
PMID: 32529856
Drug Chem Toxicol. 2020 Jun 12;1-8. doi: 10.1080/01480545.2020.1774774. Epub 2020 Jun 12.

The Portable

Quercetin and naringenin abate diethylnitrosamine/acetylaminofluorene-induced hepatocarcinogenesis in Wistar rats: the roles of oxidative stress, inflammation and cell apoptosis.

Drug and chemical toxicology

Ahmed OM, Ahmed AA, Fahim HI, Zaky MY.
PMID: 31665932
Drug Chem Toxicol. 2019 Oct 31;1-12. doi: 10.1080/01480545.2019.1683187. Epub 2019 Oct 31.

This study was designed to assess the preventive effects and to suggest the probable mechanisms of action of quercetin and naringein in diethylnitrosamine (DEN)/2-acetylaminofluorene (2AAF)-induced hepatocarcinogenesis in Wistar male rats. The chemical-induction of hepatocarcinogenesis was performed by injection of...

Showing 1 to 12 of 357 entries